<p>The development of chronic renal failure is insidious initially causing no symptoms. As the function of the Kidneys decline over time, non-specific symptoms develop. It is not until advanced irreversable renal failure is reached are appreciable signs such as difficult to treat high blood pressure and swelling develop.&nbsp;</p>

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<p>A key assessment of renal function is the estimation of the glomerular filtration rate (eGFR) which is a measure of how well kidneys are filtering blood.&nbsp; &nbsp;Chronic Kidney disease is defined by a low eGFR&nbsp;&lt;60 mL/min/1.73 m2&nbsp; that is persistent over three or more months.&nbsp; Calculating eGFR requires measurement of creatinine in the blood.&nbsp;</p>