<p>Folate and Vitamin B12 are water-soluble B vitamins that are essential for DNA synthesis and normal production of Red blood cells, white blood cells and platelets. Low levels of Folate also called Vitamin B9 lead to anemia , muscle weakness, and numbness &amp; tingling in the extremities. Low Vitamin B12 can cause low hemoglobin, depression, irritability, neurologic deficits causing cognitive changes and motor weakness.</p>